Santini Air is Dom's business located in California at the Van Nuys Airport and is a company that focuses on stunts and aerial filming. They also supplies helicopters, airplanes, and stunt pilots for private charter use, particularly for use in films and other Hollywood-type productions. In the series Santini Air only had 4 employees. Dom, Hawke, Cait and Ed, who worked as a mechanic. Santini Air was later taken over by his niece Jo Santini after his death in 1987.

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Santini Air is located at the Van Nuys Airport and when they were shooting Airwolf they used the hangars at Jetcopters, Inc regularly as the site of "Santini Air".

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• The entrance to the lair is located at the Hidden Bridge straight across Moccasin Arch.

• The chimney AW hovers out of is located at Thunderbird Mesa.

• When AW seeing leaving the lair at a distance before passing the camera, and the driving towards the lair is located near West Mitten Butte.